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Modified Chitosan-Based Hemostatic Dressings Incorporating Heparin-Loaded Nanoparticles for Enhanced Hemostatic
Despoina Meimaroglou1, Evi Christodoulou1, Rizos Evangelos Bikiaris2
1Laboratory of Polymer and Colors Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Pharmaceutics
|March 28, 2026
Summary
This study developed advanced chitosan dressings with heparin-loaded nanoparticles for effective hemostasis. These dual-function wound care materials promote rapid bleeding control and support healing, especially for high-risk patients.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Nanotechnology in Medicine
Background:
- Effective hemostasis is critical for wound healing, particularly after trauma or surgery.
- Severe bleeding necessitates advanced hemostatic agents.
- Current treatments may require improved hemostatic and anticoagulant functionalities.
Purpose of the Study:
- To develop novel chitosan-based dressings incorporating heparin-loaded poly(butylene succinate) nanoparticles.
- To combine rapid topical hemostasis with controlled anticoagulant release for enhanced wound healing.
- To create a dual-function system for managing bleeding and modulating thrombotic processes.
Main Methods:
- Chitosan was chemically modified with MES and AMPS to improve swelling and hemostatic properties.
- Heparin (Hep)-loaded poly(butylene succinate) (PBSu) nanoparticles were synthesized via emulsion method.
- Modified chitosan derivatives were combined with Hep-loaded nanoparticles to create composite dressings, characterized for morphology, swelling, loading capacity, and release kinetics.
Main Results:
- The developed dressings demonstrated rapid topical hemostasis via the chitosan matrix.
- Controlled heparin release from PBSu nanoparticles was achieved, aiming to modulate fibrin deposition and support perfusion.
- In vitro and in vivo studies confirmed the potential of the system in promoting rapid hemostasis.
Conclusions:
- The integration of modified chitosan and Hep-loaded nanoparticles presents a promising strategy for advanced wound care.
- This dual-function system offers a novel approach to hemostatic technologies.
- The developed dressings show potential for improving outcomes in patients with high bleeding risk or thrombotic conditions.
