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Updated: Mar 29, 2026
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Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
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Botanical and Upcycled Bioactives for Advanced Topical Formulations: Mechanistic Pathways, Cutaneous Delivery, and
Salvatore Panza1,2, Beatrice Pellegrini1,2, Dorotea Fiore3
1Department of Experimental and Clinical Medicine, University of Catanzaro "Magna Graecia", Viale "S. Venuta s.n.c.", I-88100 Catanzaro, Italy.
Pharmaceutics
|March 28, 2026
Summary
Natural cosmetics leverage plant compounds for skin health, using advanced delivery systems to enhance efficacy. Sustainable practices and safety are key to developing effective, eco-friendly dermatological formulations.
Area of Science:
- Dermatological science and cosmetic innovation.
- Integration of plant-derived compounds with advanced delivery systems.
- Focus on sustainability and regulatory frameworks in cosmetic development.
Background:
- Botanical ingredients modulate skin pathways like oxidative stress and inflammation.
- Challenges include ingredient instability, variability, and poor skin penetration.
- Sustainability is crucial, involving circular economy strategies and green extraction.
Purpose of the Study:
- To provide a mechanistically oriented analysis of botanical ingredients in dermatology.
- To emphasize molecular pathways, skin delivery science, and safety.
- To propose a translational framework for developing effective and safe dermatological formulations.
Main Methods:
- Structured literature search for a narrative review.
- Analysis of botanical ingredients' molecular pathways and biological effects.
- Evaluation of advanced delivery systems and sustainability strategies.
Main Results:
- Botanical compounds offer therapeutic benefits for skin regeneration and homeostasis.
- Advanced delivery systems (e.g., nanoparticles, vesicles) improve bioavailability and targeting.
- Sustainable practices are reshaping cosmetic innovation, with evolving regulations.
Conclusions:
- A framework linking phytochemistry, delivery science, safety, and sustainability is proposed.
- Rational development of effective and safe dermatological formulations is supported.
- The review emphasizes mechanistic understanding and translational science.
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