Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

4.3K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Rao et al. Ensemble Deep-Learning-Based Prognostic and Prediction for Recurrence of Sporadic Odontogenic Keratocysts on Hematoxylin and Eosin Stained Pathological Images of Incisional Biopsies. <i>J. Pers. Med.</i> 2022, <i>12</i>, 1220.

Journal of personalized medicine·2026
Same author

Precision immuno-oncology in oral cancer: latest trends in biomarkers, novel drug development and nanoparticle-based therapeutic platforms.

Frontiers in cell and developmental biology·2026
Same author

Active site groove volume may influence the DD-carboxypeptidase activity of <i>E. coli</i> DacD.

Journal of biomolecular structure & dynamics·2026
Same author

Multi-spectroscopic and computational studies of esculetin/esculin-ovalbumin interactions at molecular level: Effects of metal ions and pH on binding, inhibition of amyloid aggregation.

International journal of biological macromolecules·2026
Same author

Comparative Evaluation of Erich Arch Bars with Hybrid Arch Bars for Maxillomandibular Fixation in the Treatment of Mandibular Fractures: A Prospective Clinical Study.

Journal of maxillofacial and oral surgery·2026
Same author

Unicystic ameloblastoma: Systematic review of clinico-pathologic features and treatment outcomes in infants, children and young adults.

National journal of maxillofacial surgery·2026
Same journal

Correction: Yalçın et al. Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes. <i>Life</i> 2025, <i>15</i>, 722.

Life (Basel, Switzerland)·2026
Same journal

Correction: Schubert et al. Minimally Invasive Ablation Strategies for Renal Cell Carcinoma Patients Ineligible for Surgery. <i>Life</i> 2026, <i>16</i>, 73.

Life (Basel, Switzerland)·2026
Same journal

Blood Group Antigen Combinations and COVID-19: Complexity, Associations and Possible Clinical Relevance.

Life (Basel, Switzerland)·2026
Same journal

Beyond HPV in Eastern Europe: Genotype Distribution, Molecular Biomarkers, Vaginal Microbiome, and Implications for Cervical Cancer Prevention.

Life (Basel, Switzerland)·2026
Same journal

Therapeutic Effects of <i>Scutellaria baicalensis</i> Georgi Extract and Baicalein on Olfactory Dysfunction and Neurobehavioral Alterations in a Methimazole-Induced Injury Model.

Life (Basel, Switzerland)·2026
Same journal

The Effects of Unstable Strength Training on Lower Limb Stability in Adolescent Volleyball Players in China.

Life (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Mar 29, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.8K

Transcriptomic Profiling Identifies a Distinct Molecular Signature in OSMF-Derived Oral Squamous Cell Carcinoma.

Kavitha Prasad1, Sowmya Samudrala Venkatesiah2, Dominic Augustine2

  • 1Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru 560054, Karnataka, India.

Life (Basel, Switzerland)
|March 28, 2026
PubMed
Summary
This summary is machine-generated.

Oral Submucous Fibrosis (OSMF) progression to Oral Squamous Cell Carcinoma (OSCC) involves distinct molecular changes. Transcriptomic profiling reveals that OSMF-derived OSCC has a unique gene expression profile compared to de novo OSCC.

Keywords:
genomic landscapemouth neoplasmoral submucous fibrosistranscriptome analysis

More Related Videos

Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq
10:22

Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq

Published on: October 31, 2025

811
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.4K

Related Experiment Videos

Last Updated: Mar 29, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.8K
Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq
10:22

Comprehensive Spatial Profiling of Species-agnostic Transcriptomes via Stereo-seq

Published on: October 31, 2025

811
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.4K

Area of Science:

  • Oncology
  • Genomics
  • Oral Pathology

Background:

  • Oral Submucous Fibrosis (OSMF) is a significant oral health concern, particularly in India.
  • OSMF carries a high risk of malignant transformation into Oral Squamous Cell Carcinoma (OSCC).

Purpose of the Study:

  • To investigate the molecular mechanisms driving OSMF to OSCC transformation.
  • To compare the transcriptomic landscape of OSMF-derived OSCC with de novo OSCC.

Main Methods:

  • High-throughput RNA sequencing was employed on fresh de novo OSCC and OSMF-derived OSCC samples.
  • Differential gene expression analysis identified significant gene alterations (log2 fold change ≥2, p-value ≤0.05).

Main Results:

  • Upregulated genes in OSMF-derived OSCC are linked to immune responses, proliferation, and metabolic adaptations.
  • Downregulated genes involve epithelial differentiation, immune regulation, and tumor suppression.
  • Pathway analysis indicated altered muscle development and embryonic signaling.

Conclusions:

  • OSMF-derived OSCC presents a distinct transcriptomic profile compared to de novo OSCC.
  • Key differences include altered epithelial differentiation, immune modulation, and activated developmental pathways.
  • The fibrotic environment significantly impacts the transcriptional architecture of OSCC arising from OSMF.