Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

59.4K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.4K
Long-term Potentiation01:25

Long-term Potentiation

3.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An out-of-the-lab evaluation of dry EEG technology on a large-scale motor imagery brain-computer interface dataset.

Journal of neural engineering·2025
Same author

Electrical spinal cord stimulation promotes focal sensorimotor activation that accelerates brain-computer interface skill learning.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Personalized<i>µ</i>-transcranial alternating current stimulation improves online brain-computer interface control.

Journal of neural engineering·2025
Same author

Personalized μ-transcranial alternating current stimulation improves online brain-computer interface control.

Journal of neural engineering·2025
Same author

Novel AIRTrode-based wearable electrode supports long-term, online brain-computer interface operations.

Journal of neural engineering·2024
Same author

Personalized whole-brain activity patterns predict human corticospinal tract activation in real-time.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Mar 29, 2026

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.8K

Reopening Motor Learning Windows: Targeted Re-Engagement of Latent Pathways via Non-Invasive Neuromodulation.

Diego Mac-Auliffe1, Akhil Surapaneni2, José Del R Millán2,3

  • 1Center for Perceptual Systems, Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA.

Life (Basel, Switzerland)
|March 28, 2026
PubMed
Summary

Motor recovery after neurological injury involves relearning, not just restitution. Precise timing of stimulation, guided by Hebbian principles, can re-engage neural plasticity for lasting functional improvements in neurorehabilitation.

Keywords:
Hebbian plasticitybrain–computer interfaceclosed-loop stimulationcortical–spinal connectivitymotor learningmotor recoveryneuromodulationneurorehabilitationplasticity windowsspike-timing-dependent plasticity

More Related Videos

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
08:29

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

Published on: November 7, 2025

525
Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
08:26

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

7.2K

Related Experiment Videos

Last Updated: Mar 29, 2026

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.8K
Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation
08:29

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

Published on: November 7, 2025

525
Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain
08:26

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

7.2K

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Neuroplasticity

Background:

  • Motor recovery after neurological injuries (stroke, spinal cord injury, traumatic brain injury) is complex.
  • Surviving neural circuits possess plasticity that can be harnessed for recovery.

Purpose of the Study:

  • To synthesize findings on the mechanisms governing neural reorganization.
  • To establish a framework for neurorehabilitation based on experience-dependent plasticity.

Main Methods:

  • Review of convergent findings on Hebbian and spike-timing-dependent plasticity.
  • Analysis of mechanisms across cortical, striatal, and spinal levels.
  • Examination of factors influencing plasticity expression.

Main Results:

  • Neural reorganization relies on Hebbian and spike-timing-dependent mechanisms.
  • Temporally precise stimulation can re-engage plasticity for durable changes.
  • Recovery depends on temporal precision, physiological state, and reinforcement, not just intensity.

Conclusions:

  • Experience-dependent reorganization follows intrinsic timing rules.
  • A translational framework for neurorehabilitation can be built on these principles.
  • Biomarker-guided, adaptive strategies are key for effective neurorehabilitation.