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Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Curcumin-Loaded Lactoferrin/Pectin Core-Shell Structured Microgel Nanoparticles: Dual Regulatory Effects in

Ming-Yu Jin1, Sai-Yin Yu2, Er-Feng Wang1

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This summary is machine-generated.

Novel microgel nanoparticles loaded with curcumin (Cur) improve its bioavailability for inflammatory bowel disease (IBD) treatment. These nanoparticles enhance gut health by modulating the gut microbiota and reducing inflammation.

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Area of Science:

  • Biomaterials Science
  • Gastroenterology
  • Microbiology

Background:

  • Curcumin (Cur) shows therapeutic promise for inflammatory bowel disease (IBD).
  • Poor bioavailability of Cur limits its clinical application in IBD management.

Purpose of the Study:

  • To develop Cur-loaded core-shell structured microgel nanoparticles (LF/CP-Cur MN) to enhance Cur bioavailability.
  • To evaluate the efficacy of LF/CP-Cur MN in an IBD mouse model.

Main Methods:

  • Fabrication of LF/CP-Cur MN via electrostatic complexation of lactoferrin and citrus pectin, followed by Ca2+ consolidation.
  • Assessment of Cur release, bitterness, and astringency.
  • Evaluation of LF/CP-Cur MN in an IBD mouse model, including gut microbiota analysis and intestinal barrier integrity assessment.

Main Results:

  • LF/CP-Cur MN reduced Cur bitterness and astringency, prolonging its release.
  • Treatment with LF/CP-Cur MN mitigated IBD symptoms and inflammation in mice.
  • LF/CP-Cur MN enhanced colon-targeted Cur accumulation, restored intestinal barrier integrity, and favorably modulated gut microbiota composition.
  • Beneficial gut bacteria genera (e.g., Lactobacillus, Dubosiella) increased, while harmful genera (e.g., Enterobacter) decreased, leading to increased acetate, propionate, and butyrate levels.

Conclusions:

  • LF/CP-Cur MN significantly improve Cur bioaccessibility and delivery.
  • LF/CP-Cur MN demonstrate dual functionality in modulating gut microbiota and alleviating inflammation.
  • LF/CP-Cur MN represent a promising dietary strategy for IBD management.