Associations of TyG-Derived Indices with Cardiometabolic Multimorbidity Risk in Community-Dwelling Older Adults: A...

Cardiometabolic multimorbidity (CMM) significantly reduces healthy life expectancy in older adults. The specific role of adiposity indices derived from the triglyceride-glucose (TyG) index, body mass index (BMI), and waist-to-height ratio (WHtR) in predicting incident CMM has not been fully elucidated in longitudinal settings. We investigated these associations and the mediating role of the atherogenic index of plasma (AIP).

We analyzed 304,586 community-dwelling adults aged ≥65 years from the prospective Guangzhou Older Longitudinal Dynamic Health (GOLD-Health) cohort (2018-2019), who were free of CMM at baseline. Multivariable Cox proportional hazards models evaluated the risk of incident CMM (coexistence of ≥2 cardiometabolic diseases) across quartiles of six TyG-derived indices. Mediation analysis quantified the contribution of atherogenic dyslipidemia via AIP.

Following a median observation time of 4.3 years, the study recorded 7816 participants who developed CMM. All six indices showed significant positive associations with CMM risk. TyG-WHtR demonstrated the strongest association (Hazard Ratio [HR] comparing highest vs. lowest quartile = 2.150; 95% Confidence Interval [CI] 1.998-2.314), closely followed by TyG-BMI (HR = 2.146). AIP significantly mediated the associations, explaining 7.5-33.0% of the effect, with the highest proportion observed for TyG using the Chinese visceral adiposity index (CVAI).

TyG-derived adiposity indices, particularly TyG-WHtR and TyG-BMI, are robust independent risk markers for incident CMM in older adults. The substantial mediating role of AIP suggests that targeting atherogenic dyslipidemia may be a key strategy to interrupt the progression from insulin resistance to multimorbidity. These accessible metrics hold promise for large-scale risk stratification and early intervention in primary care settings.