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Myricetin Nanofibers as Amorphous Delivery System
Natalia Rosiak1, Wojciech Rydyger1, Andrzej Miklaszewski2
1Department of Pharmacognosy and Biomaterials, Faculty of Pharmacy, Poznan University of Medical Sciences, 3 Rokietnicka St., 60-806 Poznan, Poland.
Pharmaceuticals (Basel, Switzerland)
|March 28, 2026
Summary
Electrospun nanofibers significantly improved myricetin solubility and antioxidant activity. This novel delivery system enhances poorly soluble compounds for potential pharmaceutical applications.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Nanotechnology
Background:
- Myricetin (MYR) is a potent flavonol with diverse bioactivities but suffers from poor aqueous solubility and oral bioavailability.
- Limited solubility hinders the pharmaceutical application of MYR, necessitating advanced delivery systems.
Purpose of the Study:
- To enhance the solubility and bioavailability of myricetin (MYR) through the development of an amorphous nanofibrous delivery system.
- To investigate the influence of electrospinning parameters on MYR solubility and characterize the resulting nanofibers.
Main Methods:
- Fabrication of MYR-loaded nanofibers using electrospinning with polyvinylpyrrolidone K30 (PVP30).
- Characterization of nanofibers using X-ray powder diffraction, FTIR, and SEM.
- Evaluation of solubility, dissolution behavior, and antioxidant activity.
Main Results:
- Complete amorphization of MYR within PVP30 nanofibers was confirmed by X-ray powder diffraction.
- FTIR analysis revealed hydrogen bonding between MYR and PVP30, stabilizing the amorphous form.
- Enhanced solubility led to a 'spring-and-parachute' release effect and significantly improved antioxidant activity.
Conclusions:
- Electrospun PVP30 nanofibers provide a promising platform for enhancing the solubility and functional activity of poorly soluble compounds like myricetin.
- This approach supports the potential pharmaceutical formulation of MYR and similar bioactive molecules.
- The developed nanofibrous system demonstrates improved dissolution behavior and increased efficacy.
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