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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Related Experiment Video

Updated: Mar 29, 2026

Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation
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Development of a Novel Internal Fixation Model for Rat Radial Fractures: Fracture Healing Assessment and Dorsal Root Ganglion Isolation

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Bioabsorbable Hydrogel Coating for Infection Prevention in Fracture Fixation: A Retrospective Matched Case-Control

Carlo Ciccullo1, Marco Grassi1, Marco Antonio Carletti1

  • 1Clinical Orthopedics, Department of Clinical and Molecular Sciences, Università Politecnica delle Marche Azienda Ospedaliera Universitaria delle Marche, Via Conca 71, 60126 Ancona, Italy.

Pharmaceuticals (Basel, Switzerland)
|March 28, 2026
PubMed
Summary
This summary is machine-generated.

A novel antibiotic-free hydrogel coating (DAC®) significantly reduced postoperative infections and wound complications in orthopedic trauma patients. This promising strategy offers a new approach to enhance patient safety and outcomes in complex fracture surgeries.

Keywords:
DAChospital-acquired infectionshydrogelinfectionstrauma surgery

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Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Infectious Disease Prevention

Background:

  • Hospital-acquired and fracture-related infections are significant complications in orthopedic trauma.
  • Antibacterial implant coatings offer a strategy to mitigate early bacterial adhesion and biofilm formation.

Purpose of the Study:

  • To evaluate the clinical effectiveness of an antibiotic-free hydrogel coating (DAC®) applied intraoperatively to orthopedic implants.
  • To assess the impact of the DAC® coating on infection incidence, wound complications, and bone healing.

Main Methods:

  • Retrospective matched case-control study involving 222 orthopedic trauma patients with comorbidities.
  • Comparison of DAC®-coated implants versus standard fixation in open reduction and internal fixation procedures.
  • Primary endpoint: infection incidence within 6 months; secondary endpoints: wound complications, revision surgery, and bone healing.

Main Results:

  • Significantly lower postoperative infection incidence in the DAC® group (0.7%) compared to controls (5.3%; p=0.0363).
  • Reduced wound complications in the DAC® cohort (1.3%) versus controls (8.0%; p=0.028).
  • Comparable bone healing outcomes and minimal need for revision surgery or prolonged antibiotics in the DAC® group.

Conclusions:

  • Intraoperative use of the antibiotic-free DAC® hydrogel coating is a safe and promising strategy for reducing early postoperative infections and wound complications.
  • Further prospective studies are warranted to confirm long-term safety and effectiveness.
  • DAC® hydrogel represents a potential advancement in managing orthopedic trauma patients with comorbidities.