Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effect of Statin Therapy on the Overall Survival of Patients with Hepatocellular Carcinoma: A Single-Center Experience.

Cancers·2026
Same author

ECCO Guidelines on the Prevention, Diagnosis, and Management of Infections in Inflammatory Bowel Disease.

Journal of Crohn's & colitis·2026
Same author

Vasa Vasorum-A Silent Enemy After EVAR: A Case Report and Review of the Literature.

Clinics and practice·2026
Same author

Intravascular lithotripsy for coral reef aortic stenosis: a case series assessing feasibility, hemodynamic effects, imaging and clinical outcomes.

CVIR endovascular·2026
Same author

Comparison of Three International Definitions for Overweight and Obesity in a Population of Adolescents in Greece.

Journal of personalized medicine·2026
Same author

Computed Tomography Coronary Angiography as a Gatekeeper for Invasive Coronary Assessment Before Transcatheter Aortic Valve Implantation.

Medicina (Kaunas, Lithuania)·2026

Related Experiment Video

Updated: Mar 29, 2026

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.8K

Fractional Flow Reserve Derived from a Single Angiographic View: Fact or Fiction?

Michail I Papafaklis1,2, Anastasios Papoutsoglou2, George C Bourantas3

  • 1Faculty of Medicine, School of Health Sciences, University of Patras, 26504 Rio, Greece.

Medicina (Kaunas, Lithuania)
|March 28, 2026
PubMed
Summary

Accurate assessment of coronary artery stenoses is crucial for patient outcomes. Single-view angiography-derived fractional flow reserve (FFR) offers a simpler, wire-free alternative to invasive FFR, improving accessibility for coronary artery disease management.

Keywords:
angiographycatheterizationcomputationcoronary artery diseasefunctional assessment

More Related Videos

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
05:56

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Published on: August 9, 2024

2.8K
Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice
05:07

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice

Published on: August 25, 2023

2.2K

Related Experiment Videos

Last Updated: Mar 29, 2026

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.8K
Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis
05:56

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Published on: August 9, 2024

2.8K
Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice
05:07

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice

Published on: August 25, 2023

2.2K

Area of Science:

  • Cardiology
  • Medical Imaging
  • Computational Fluid Dynamics

Background:

  • Accurate assessment of coronary artery stenosis is vital for guiding revascularization in coronary artery disease (CAD).
  • Invasive wire-based fractional flow reserve (FFR) is the gold standard but faces limitations in routine clinical adoption due to complexity and cost.
  • Development of non-invasive, angiography-derived FFR techniques is crucial for broader application.

Purpose of the Study:

  • To review the principles, validation, and clinical utility of single-view angiography-derived FFR technologies.
  • To highlight the potential of these methods to increase the adoption of physiology-guided coronary interventions.
  • To compare the performance of various single-view FFR techniques, particularly µQFR.

Main Methods:

  • Review of existing literature on single-view angiography-derived FFR techniques.
  • Analysis of validation data comparing non-invasive methods with invasive FFR.
  • Discussion of computational modeling, AI, and image processing in FFR estimation from coronary angiography.
  • Focus on methods like Murray law-based quantitative flow ratio (µQFR), FFR2D, Angio-iFR/FFR, sAccuFFR, and X1-FFR.

Main Results:

  • Single-view angiography-derived FFR methods simplify physiological evaluation without pressure wires or hyperaemia.
  • µQFR shows consistent validation against invasive FFR across diverse clinical scenarios, including complex lesions and acute coronary syndromes.
  • These techniques aim to maintain diagnostic accuracy while streamlining the workflow for coronary interventions.

Conclusions:

  • Single-view angiography-derived FFR technologies offer a promising, less invasive alternative to traditional invasive FFR.
  • µQFR demonstrates robust performance and broad applicability in assessing coronary stenosis significance.
  • Wider adoption of these simplified physiological assessment tools can enhance the management of patients with coronary artery disease.