Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

1.7K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.7K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.4K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.4K
Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

5.6K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
5.6K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

3.4K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
3.4K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.4K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.4K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

1.0K
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxytocin and RAGE signaling at the intersection of social neurodevelopment and inflammation.

Journal of translational medicine·2026
Same author

Single-cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease.

bioRxiv : the preprint server for biology·2026
Same author

Microglia respond to and induce anxiety and grooming in mice using calcium signaling.

Molecular psychiatry·2026
Same author

Experimental and computational methods for allelic imbalance analysis from single-nucleus RNA-seq data.

Genome biology·2026
Same author

Integrating Long-Read Structural Variant Analysis with single-nucleus RNA-seq to Elucidate Gene Expression Effects in Disease.

bioRxiv : the preprint server for biology·2026
Same author

Defective Hoxb8 microglia are causative for both chronic anxiety and pathological overgrooming in mice.

Molecular psychiatry·2025

Related Experiment Video

Updated: Mar 29, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

815

Cerebellar Abnormalities: A Component of Autism Pathophysiology.

Rekha Jagadapillai1,2, Idil Tuncali1,2, Naveen Nagarajan1,2

  • 1Department of Pediatrics, Pediatric Research Institute (PRI), University of Louisville, Louisville, KY 40202, USA.

Medicina (Kaunas, Lithuania)
|March 28, 2026
PubMed
Summary

The cerebellum plays a crucial role in autism spectrum disorder (ASD) development. Cerebellar dysfunction impacts brain development and social behaviors, suggesting it as a potential therapeutic target for ASD.

Keywords:
astrogliaautismautism signaling pathwaysautism-linked genescerebellumneurodevelopmental disease

More Related Videos

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.8K
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.9K

Related Experiment Videos

Last Updated: Mar 29, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

815
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.8K
Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.9K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Autism spectrum disorder (ASD) is a complex developmental disorder diagnosed behaviorally.
  • Current diagnostic methods lack validated biomarkers.
  • The cerebellum's role in ASD pathophysiology has been historically under-researched.

Purpose of the Study:

  • To review the cerebellum's potential role in ASD development.
  • To explore how cerebellar dysfunction may influence connected neural circuits.
  • To investigate the cerebellum's impact on core ASD symptoms.

Main Methods:

  • Literature review focusing on cerebellar function in ASD.
  • Analysis of developmental and early injury impacts on cerebellar circuitry.
  • Examination of cerebellar alterations and their link to ASD symptoms.

Main Results:

  • Cerebellar alterations in ASD affect synaptic pruning, immune function, and neurotransmitter systems.
  • Changes in the cerebellum can impact blood-brain barrier permeability and signaling pathways.
  • Cerebellar dysfunction is implicated in altered brain interconnections and developmental trajectories.

Conclusions:

  • Cerebellar dysfunction is a significant factor in ASD pathophysiology.
  • Interactions within the cerebellum may contribute to core ASD symptoms.
  • Further research into cerebellar mechanisms could yield novel ASD therapies.