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Updated: Mar 29, 2026

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Neonatal Sepsis-Induced Coagulopathy in the Light of Developmental Hemostasis: Friend or Foe?

Paraskevi Papadogeorgou1,2, Rozeta Sokou1, Sotirios P Fortis3

  • 1Neonatal Department, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece.

Medicina (Kaunas, Lithuania)
|March 28, 2026
PubMed

Insights

Children

Area of Science:

  • Pediatrics
  • Hematology
  • Neonatology

Background:

  • Developmental hemostasis highlights significant differences in blood clotting between children and adults, especially in neonates.
  • These differences are more pronounced in preterm infants and can lead to severe complications like intraventricular hemorrhage.
  • Understanding these variations is crucial as more premature infants survive, impacting long-term neurodevelopmental outcomes.

Purpose of the Study:

  • To review the developmental aspects of coagulation in neonates.
  • To explore the impact of neonatal sepsis on hemostatic derangements.
  • To emphasize the importance of understanding neonatal coagulation for timely diagnosis and treatment.

Main Methods:

  • Literature review focusing on developmental hemostasis.
  • Analysis of coagulation abnormalities in neonatal sepsis.
  • Exploration of hemorrhagic and thrombotic complications in neonates.

Main Results:

  • Neonatal coagulation differs significantly from adult hemostasis, with greater variations in preterm infants.
  • Neonatal sepsis is a major trigger for coagulation abnormalities, impacting clinical outcomes.
  • Despite initial protective roles, coagulation activation in sepsis can lead to adverse effects.

Conclusions:

  • Children's hemostasis is distinct, not simply a smaller version of adult systems.
  • Effective management of neonatal coagulation disorders, particularly in sepsis, is vital for improving prognosis.
  • A comprehensive understanding of developmental hemostasis is essential for pediatric and neonatal care.

Keywords:
coagulationdevelopmental hemostasisneonatessepsissepsis-induced coagulopathy

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