Bisphenol-A Release from Modern Resin-Based Dental Composites: A Time-Dependent In Vitro Assessment

Area of Science:

• Dental Materials Science
• Toxicology
• Analytical Chemistry

Background:

• Resin-based dental composites are prevalent in restorative dentistry.
• Concerns exist regarding the release of Bisphenol-A (BPA), an endocrine-disrupting compound, from these materials.
• Understanding BPA release kinetics is crucial for patient safety.

Purpose of the Study:

• To evaluate the time-dependent release of BPA from four contemporary dental composites.
• To investigate the influence of different thermal conditions (37°C and 44°C) on BPA release.
• To compare BPA leaching profiles among selected resin-based materials.

Main Methods:

• Disk-shaped specimens of four dental composites were incubated in artificial saliva (pH 6.8).
• Samples were analyzed for BPA concentrations at 1, 7, and 28 days using UHPLC-MS/MS.
• Two incubation temperatures (37°C and 44°C) were employed.

Main Results:

• BPA release was detected in three of the four materials tested (Estelite Sigma Quick, Clearfil Majesty ES-2, Omnichroma Flow).
• Luna 2 showed no quantifiable BPA release under tested conditions.
• Highest BPA concentrations were observed after 1 day, especially at 44°C, with release decreasing over time.
• Estelite Sigma Quick demonstrated the highest BPA release, followed by Clearfil Majesty ES-2 and Omnichroma Flow.

Conclusions:

• BPA release from dental composites is material-dependent, influenced by temperature and duration.
• While absolute BPA levels were low, findings underscore the need for material-specific assessment.
• Continuous monitoring of potential cumulative BPA exposure from dental materials is warranted.