IMU-Based Wearable Insoles in Clinical Settings: Key Parameters Differentiating Clinical and Non-Clinical Populations

Wearable systems based on inertial measurement units (IMUs) have attracted considerable interest in recent years in the field of gait analysis. However, most gait studies using such devices have been conducted in laboratory rather than clinical settings. This study evaluated a commercially available IMU-based insole system in two cohorts: a clinical group (59 ± 18, years) recruited from podiatry clinics and a non-clinical group (28 ± 7, years) recruited from a university with no reported complaints. Participants wore the IMU-based device and performed treadmill walking (clinical group) and overground walking (non-clinical group). Spatiotemporal parameters were compared between groups using statistical analyses included the Shapiro-Wilk test, Mann-Whitney test, and Welch's t-tests for non-bilateral data, and a two-factor linear mixed-effects model estimated by restricted maximum likelihood (REML) for bilateral spatiotemporal parameters to evaluate group, foot-side, and interaction effects. Ten of the twenty-two spatiotemporal parameters showed significant group differences, with statistical significance observed in at least one foot for parameters measured bilaterally. The observed differences may reflect a combination of clinical characteristics, age-related effects, and walking environment influences. Findings are discussed in relation to potential biomechanical mechanisms, factors influencing results and the clinical utility of IMU systems. Future research should investigate specific foot conditions under standardized walking conditions with age-matched cohorts.