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Extended HPV typing as an efficient alternative within HPV-based screening programs.

Joacim Meneses-León1, Berenice Rivera-Paredez1, Sonia Hernández-Salazar1

  • 1Research Center in Policy, Population, and Health, School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

International Journal of Cancer
|March 28, 2026
PubMed
Summary
This summary is machine-generated.

Extended high-risk human papilloma virus (hrHPV) typing can effectively detect cervical intraepithelial neoplasia 3 (CIN3). This hrHPV genotyping strategy achieves 100% sensitivity for CIN3 detection, improving cervical cancer screening.

Keywords:
HPVHPV‐based screening programextended typingtriage

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Area of Science:

  • Gynecology
  • Oncology
  • Virology

Background:

  • Cervical cancer screening programs rely on human papillomavirus (HPV) testing.
  • Current methods may require additional triage tests for accurate diagnosis.
  • Extended high-risk HPV (hrHPV) typing offers a potential improvement for detecting cervical intraepithelial neoplasia 3 (CIN3).

Purpose of the Study:

  • To evaluate extended hrHPV typing as a standalone method for improving CIN3 detection within an HPV-based screening program.
  • To assess the sensitivity and specificity of extended hrHPV genotyping for CIN3 detection.

Main Methods:

  • A cohort of 5856 women aged 25-65 years participated in a public cervical cancer screening program.
  • HPV testing was performed using BD Onclarity™ for individual and pooled hrHPV types, with further identification by Atila AmpFire.
  • HPV-positive women (n=691) underwent colposcopy and histological confirmation (n=561).

Main Results:

  • HPV-16 alone showed 43.0% sensitivity and 85.4% specificity for CIN3.
  • Adding HPV-18, 33, 31, and 39 increased sensitivity to 100% for CIN3 detection, with specificity at 54.5%.
  • Extended genotyping (HPV-16/18/33/31/39) achieved 100% sensitivity for CIN3 detection, aligning with international recommendations for colposcopy referral.

Conclusions:

  • Extended hrHPV genotyping demonstrates high sensitivity for detecting CIN3.
  • This strategy can serve as an effective alternative for CIN3 detection in HPV-based screening programs.
  • The findings support the use of extended hrHPV genotyping for improved cervical cancer screening outcomes.