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Published on: April 23, 2012
A Novel Composite Additive Based on Modified Eggshell Powder for the Adsorption and Toxicity Mitigation of
Changao Geng1,2, Chongqi Zhao1,2, Jiani Jiang1,2
1Hunan Provincial Key Laboratory for the Products Quality Regulation of Livestock and Poultry, College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, P. R. China.
Abstract:
Deoxynivalenol (DON), a prevalent mycotoxin in crops, poses significant risks to public health. Single-component DON adsorbents exhibit poor polar affinity and limited binding sites. This study aims to develop a novel composite adsorbent capable of adsorption and toxicity mitigation against DON. Eggshell-based composite adsorbents (EC-1, EC-2, and EC-3) were developed by blending 500-CSAE (a novel adsorbent based on eggshell powder modification) with coconut shell biochar, yeast cell walls, and honeysuckle extract at ratios of 3:1:1:2, 2:2:1:2, and 1:3:1:2, respectively. The preferred EC-1 achieved adsorption of 99.7% and 99.5% for DON in simulated gastric and intestinal environments, respectively. EC-1 at 50, 100, and 200 μg/mL showed no cytotoxicity and counteracted DON-induced viability loss of IPEC-J2 cells. Dietary supplement with 0.2% EC-1 attenuated DON-compromised growth performance, liver function, immune function, antioxidant capacity, and intestinal morphology of piglets. In conclusion, EC-1 was developed and validated as a food additive for mitigating DON hazards.
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