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Updated: Mar 30, 2026

Measuring RAN Peptide Toxicity in C. elegans
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Polyglutamine homorepeat regulates Runx2 condensation and cellular localization in a KPNA3-dependent manner

Jia Hui Weng1, Shui Bo Xu1, Jia Chen Lv1

  • 1Department of Orthopaedic Surgery of the Second Affiliated Hospital and Department of Biochemistry, Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.

Cell Reports
|March 28, 2026
PubMed

Keywords:
CP: cell biologyCP: developmental biologyCleidocranial dysplasiaKaryopherinRunx2homorepeatimportinosteogenesisphase separationpolyQ repeat“steric hindrance” model

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