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Updated: Mar 30, 2026

High-Density DNA and RNA microarrays - Photolithographic Synthesis, Hybridization and Preparation of Large Nucleic Acid Libraries
Published on: August 12, 2019
Ugi-Type Reaction Enables Access to Fused Imidazole Derivatives for DNA-Encoded Library Technology
Hao Guo1, Zitao Li1, Gaonan Wang1
1WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Abstract:
This study presents a DNA-compatible synthesis of diverse N-fused imidazopyridines via a catalyst-free Ugi-type multicomponent reaction using TMSCN as a functional isonitrile equivalent. The desilylation activation occurs efficiently in water without additional catalysts. The method exhibits a broad substrate scope for aldehydes and heterocyclic amidines and excellent chemoselectivity, underscoring its utility for constructing privileged heteroaromatic scaffolds in DNA-encoded library technology.
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