Exercise increases transglutaminase 2 expression in skeletal muscle.

Area of Science:

• Muscle physiology
• Molecular biology
• Exercise science

Background:

• Transglutaminase 2 (TG2) is recognized as a myokine that promotes skeletal muscle hypertrophy.
• Understanding the molecular mechanisms regulating TG2 expression during exercise is crucial for muscle adaptation research.

Purpose of the Study:

• To investigate the relationship between endurance exercise and TG2 mRNA expression.
• To elucidate the molecular pathways, specifically involving PGC-1α4 and ATF6α, that regulate TG2 mRNA expression during endurance exercise.

Main Methods:

• Analysis of Tg2 mRNA expression levels in response to endurance exercise.
• Correlation analysis between Tg2 mRNA and Pgc-1α4 mRNA expression.
• Investigating the role of PGC-1α4 and ATF6α in regulating Tg2 mRNA expression.

Main Results:

• Tg2 mRNA expression levels were found to increase with endurance exercise.
• A positive correlation was observed between Tg2 mRNA and Pgc-1α4 mRNA expression levels.
• PGC-1α4 was shown to enhance Tg2 mRNA expression in conjunction with ATF6α.

Conclusions:

• Endurance exercise upregulates Tg2 mRNA expression.
• The ATF6α and PGC-1α4 signaling pathway is involved in the exercise-induced increase of Tg2 mRNA.
• These findings reveal a novel molecular mechanism linking endurance exercise to TG2 expression and potential muscle hypertrophy.