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Microbial chassis selection for niche-specific engineered live biotherapeutics.

Dongmin Byun1, Li Ting Lee1, Chenxin Zhang1

  • 1NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore, Singapore, Singapore; Synthetic Biology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; National Centre for Engineering Biology (NCEB), Singapore, Singapore; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Current Opinion in Microbiology
|March 28, 2026
PubMed
Summary

Selecting the right microbial chassis is key for engineered live biotherapeutic products (eLBPs). This review covers chassis for various body sites, aiding therapeutic development.

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