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Three new flavonoids and three new stilbenes from Macaranga indica with their cytotoxic activity
Chan Chen1, Gui-Zhi Wang1, Jing-Jing Zhang2
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy, School of Medicine and School of Chemical Science and Technology, Yunnan University, Kunming 650500, China.
Abstract:
In this study, three new prenylated flavonoids, macangoids A-C (1-3), and three new prenylated stilbenes, macangnens A-C (4-6), along with thirteen known compounds (7-19), were isolated from the twigs and leaves of Macaranga indica. Their structures were elucidated by comprehensive spectroscopic analysis, including NMR, UV, IR, and mass spectrometry. The absolute configurations of compounds 1 and 2 were determined by ECD analysis. The cytotoxic activity of some compounds was tested with IC50 in the range of 1.28 ± 0.13-40 μg/mL. Among them, the IC50 values of compounds 5 and 14 were 5.16 ± 0.18-9.51 ± 0.12 μg/mL and 4.41 ± 1.13-8.05 ± 3.32 μg/mL, respectively.
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