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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
mRNA Vaccines for Cancer Treatment
Robert J Torphy1, Vinod Balachandran2, Kevin C Soares3
1Department of Surgery, University of North Carolina School of Medicine, 4001 Burnett-Womack Building, CB #7050, Chapel Hill, NC 27599, USA.
None:
mRNA cancer vaccines offer a promising and flexible platform for personalized immunotherapy, enabling the delivery of tumor-associated or tumor-specific neoantigens to stimulate a strong antigen-specific immune response. This review outlines key principles of mRNA vaccine design, highlights emerging clinical trial data across solid tumors, and discusses current limitations. Future clinical trial efforts with mRNA cancer vaccines should focus on rational combination treatments to augment the antitumor immune response, optimizing patient selection in the adjuvant or minimal residual disease settings, and adaptive trial designs to accelerate clinical translation and broaden access to mRNA-based cancer immunotherapies.
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