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Association between changes in blood eosinophil levels and alterations in olfactory function in asthma.
Hyo-In Rhyou1, Woo Yong Bae2, Young-Hee Nam3
1Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Summary
Asthma patients show changes in smell function linked to blood eosinophil levels. Higher eosinophils correlate with declining olfactory function, suggesting a connection between inflammation and smell in asthma.
Area of Science:
- Respiratory Medicine
- Neurology
- Otolaryngology
Background:
- Olfactory dysfunction is a known comorbidity in asthma.
- The underlying mechanisms linking asthma and smell impairment remain unclear.
Purpose of the Study:
- To investigate the relationship between olfactory function changes and clinical parameters in asthma patients.
- To explore potential biomarkers associated with olfactory decline in asthma.
Main Methods:
- Prospective study of 30 moderate to severe asthma patients.
- Olfactory function assessed using the YSK Olfactory Function Test over 6 months.
- Clinical parameters, including blood eosinophil levels, were analyzed in relation to olfactory changes.
Main Results:
- Patients were categorized into olfactory-improvement (n=9), olfactory-stable (n=15), and olfactory-decline (n=6) groups.
- Blood eosinophil levels progressively increased from the improvement to the decline groups.
- No significant differences were observed in upper airway diseases, intranasal steroid use, asthma control, or medications.
Conclusions:
- Blood eosinophilic inflammation may be associated with olfactory function in asthma patients.
- Further research is warranted to elucidate the mechanisms connecting eosinophilic inflammation and olfactory dysfunction in asthma.
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