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Updated: Mar 31, 2026
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Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
Published on: May 2, 2025
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Programmed cell death: a promising management for Alzheimer's disease
Qianqian Yang1, Xinxin Ren2, Ruonan Jia2
1Hangzhou Geriatric Hospital, Department of Pharmacy, Affiliated Hangzhou First People's Hospital Chengbei Campus, School of Medicine, Westlake University, Hangzhou, China.
Summary
Programmed cell death (PCD) mechanisms are increasingly linked to Alzheimer's disease (AD) progression. Understanding these cell death pathways offers new avenues for early diagnosis and novel therapeutic strategies to combat AD.
Area of Science:
- Neuroscience
- Cell Biology
- Pathology
Background:
- Alzheimer's disease (AD) is a growing global health concern, particularly among the elderly, with limited effective interventions to slow its progression.
- Programmed cell death (PCD), a regulated cellular self-destruction process vital for homeostasis, is now recognized as a key player in AD pathogenesis.
- Multiple PCD pathways, including autophagy, ferroptosis, pyroptosis, and necroptosis, are implicated in the onset, development, and outcomes of AD.
Purpose of the Study:
- To review recent advancements in understanding the role of various PCD pathways in Alzheimer's disease.
- To explore the potential of PCD mechanisms in identifying novel biomarkers for AD diagnosis.
- To examine the application of PCD in developing innovative therapeutic strategies for AD management and prevention.
Main Methods:
- Comprehensive literature review of recent studies on programmed cell death and Alzheimer's disease.
- Synthesis of evidence linking specific PCD pathways (e.g., autophagy, ferroptosis, pyroptosis) to AD.
- Analysis of current research on PCD-based biomarkers and therapeutic targets for AD.
Main Results:
- Accumulating evidence strongly links diverse PCD modalities to the initiation, progression, and prognosis of Alzheimer's disease.
- PCD pathways are emerging as promising targets for developing sensitive biomarkers for early AD detection.
- Targeting specific PCD mechanisms presents opportunities for innovative therapeutic interventions to manage AD.
Conclusions:
- Programmed cell death pathways are critically involved in Alzheimer's disease pathogenesis and progression.
- Harnessing knowledge of PCD offers significant potential for advancing AD diagnosis through biomarker discovery.
- Exploring PCD mechanisms provides a promising avenue for developing novel therapeutic and preventive strategies for Alzheimer's disease, shifting focus towards proactive management.
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