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Clinical application and optimization strategies for antibody-drug conjugates in solid tumors

Jie Qu1, Xiaoyue Zhao2, Linzhu Zhang3

  • 1Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, China.

The Journal of International Medical Research
|March 29, 2026
PubMed

Insights

Antibody-drug conjugates offer targeted cancer therapy for solid tumors. This review explores their progress, limitations like toxicity and resistance, and future optimization strategies for improved patient outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Advanced solid tumors have a poor prognosis despite existing treatments.
  • Antibody-drug conjugates (ADCs) selectively deliver cytotoxic drugs to tumor cells.
  • ADCs represent a promising approach for broad-spectrum antitumor therapy.

Purpose of the Study:

  • To review the functionality, history, and progress of ADCs in treating solid tumors.
  • To explore optimization strategies addressing ADC limitations.
  • To enhance the efficacy and safety of ADC cancer treatment.

Main Methods:

  • Literature review of antibody-drug conjugate research.
  • Analysis of ADC functionality, iteration, and development.
  • Exploration of strategies to overcome toxicity, resistance, and permeability issues.

Main Results:

  • ADCs demonstrate selective drug delivery to tumor cells.
  • Ongoing development shows continuous improvement in ADC technology.
  • Key limitations include poor tumor permeability, toxicity, and drug resistance.

Conclusions:

  • ADCs hold significant potential for solid tumor treatment.
  • Addressing limitations is crucial for maximizing therapeutic benefits.
  • Future optimization can improve efficacy, reduce toxicity, and overcome resistance, benefiting more cancer patients.
Keywords:
Antibody–drug conjugatesclinical applicationoptimization strategysolid tumortherapeutic targets

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