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Published on: July 3, 2019
Kinetic management of endocrine disruption: How chemical dynamics shape hormonal systems
Sunday Amos Onikanni1, Omolola Esther Amos2, Tran Nhat Phong Dao3
1Centro de Ciências da Saúde, Instituto de Ciências Biomédicas, Laboratório de Endocrinologia Experimental-LEEx, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Graduate Program in Pharmacology and Medicinal Chemistry, Centro de Ciências da Saúde, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Department of Chemical Sciences, Biochemistry Unit, Afe-Babalola University, Ado-Ekiti, Ekiti State, 36001, Nigeria.
None:
Historically, the assessment of endocrine disruption has relied on fixed exposure metrics, neglecting the crucial influence of chemical kinetics on hormonal effects. This review introduces the concept of kinetic management of endocrine disruption, focusing on how factors such as absorption, tissue partitioning, metabolism, and persistence influence the degree, timing, and extent of hormonal interference. We present emerging evidence that highlights how lipophilic accumulation in endocrine organs, the bioactivity of metabolites, and delayed internal release can create a disconnect between the external dose and its biological outcomes. By fusing pharmacokinetics with the dynamics of hormone receptors, feedback regulation, and vulnerabilities specific to different life stages, we propose a holistic framework that combines toxicology, endocrinology, and predictive modeling. This kinetic‒endocrine paradigm opens up significant opportunities for advanced risk assessment, precision in endocrine health safeguarding, and the deliberate creation of safer chemicals and therapeutic solutions.
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