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Related Concept Videos

Scale-Up Processes01:14

Scale-Up Processes

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The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
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Upstream Processing01:27

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Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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Bioreactor Controls-III01:22

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Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
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Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming.

Izabela Anna Chincinska1, Dorota Sołtys-Kalina2, Audrey Y-H Teh3,4

  • 1Department of Plant Experimental Biology and Biotechnology, Laboratory of Plant Biotechnology, Faculty of Biology, University of Gdańsk, Poland.

Plant Biotechnology Journal
|March 30, 2026
PubMed
Summary

The potato is being reconsidered as a molecular farming chassis, offering advantages like long-term storage and biosafety. Advances in genetic engineering and processing may overcome past limitations for biomanufacturing.

Keywords:
Solanum tuberosumbioreactor potatogenome editingglycoengineeringplant molecular farmingprotein storage vacuolerecombinant proteinstechnoeconomic analysis

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Area of Science:

  • Plant biotechnology
  • Molecular farming
  • Biomanufacturing

Background:

  • Potatoes were early hosts for recombinant protein production, offering storage and logistical benefits.
  • Challenges like low expression, high downstream processing costs, and scalability hindered potato's widespread adoption.
  • Recent technological advancements present opportunities to re-evaluate potato as a molecular farming platform.

Purpose of the Study:

  • To review the historical context and technical/economic factors influencing potato's role in molecular farming.
  • To assess recent advancements that could overcome previous limitations.
  • To explore the potential of a 'bioreactor potato' for next-generation biomanufacturing.

Main Methods:

  • Review of technical and economic factors affecting potato molecular farming.
  • Analysis of recent advances in expression systems, pathway engineering, and downstream processing.
  • Evaluation of alternative potato germplasm and genome editing technologies.

Main Results:

  • Refined expression cassettes, ER/secretory pathway engineering, and enzyme-assisted DSP show promise.
  • Genome editing and multigene stacking offer improved control and expression.
  • Diploid potatoes and alternative Solanum germplasm provide new chassis options.

Conclusions:

  • Engineered diploid potatoes ('bioreactor potatoes') can overcome previous limitations.
  • These advancements position potato as a viable platform for specific biomanufacturing niches.
  • Potato can complement existing hosts in next-generation biomanufacturing.