Related Experiment Video
Updated: Mar 31, 2026
08:28
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
Published on: March 3, 2023
1.8K
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing.
Tommaso Curiale1, Marie Celine Lefevre1, Alessio Carmignani1
1Smart Bio-Interfaces, Istituto Italiano di Tecnologia, Pontedera, Italy.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|March 30, 2026
Summary
Recent advances in active nanomaterials offer precise neuromodulation via remotely controlled nanotransducers. These smart nanotechnologies pave the way for tailored therapies for neurological and psychiatric disorders.
Area of Science:
- Nanotechnology
- Neuroscience
- Biomedical Engineering
Background:
- Neuromodulation techniques are crucial for understanding and treating brain disorders.
- Current methods often lack spatiotemporal precision and can be invasive.
Purpose of the Study:
- To review recent advancements in active nanomaterials for precise neuromodulation.
- To explore the potential of these nanotechnologies for clinical translation in brain disorders.
Main Methods:
- Focus on stimuli-responsive nanomaterials and remotely controlled nanotransducers.
- Examination of energy transduction mechanisms in nanoparticle-assisted neuromodulation.
- Highlighting nanosensors for monitoring neural activity.
Main Results:
- Active nanomaterials enable spatiotemporally precise brain interfacing.
- Nanosensors provide high-resolution monitoring of bioelectrical and neurochemical activity.
- Strategies for targeting glial function and crossing the blood-brain barrier are emerging.
Conclusions:
- Smart nanotechnologies are foundational for next-generation precision brain interfacing.
- Potential for patient-tailored therapeutic solutions for neurological and psychiatric disorders.
- Key challenges for clinical translation include safety, biointegration, and regulation.
