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The Protective Effect of Carvacrol Against Isoproterenol-Induced Cardiotoxicity in Rats
Seyhan Ayık1, Hamza Dogukan Erfirat2, Onural Ozhan1
1Inonu University Faculty of Medicine, Department of Medical Pharmacology, Malatya, Türkiye.
Medeniyet Medical Journal
|March 30, 2026
Summary
Carvacrol (CAR) protects against isoproterenol (ISO)-induced heart injury by reducing oxidative stress and inflammation. This study shows CAR
Area of Science:
- Cardiology
- Biochemistry
- Pharmacology
Background:
- Isoproterenol (ISO) induces myocardial injury through oxidative stress (OS) and inflammation.
- Carvacrol (CAR) possesses known antioxidant and cardioprotective properties.
Purpose of the Study:
- To investigate the protective effects of carvacrol against ISO-induced myocardial injury in a rat model.
- To evaluate CAR's impact on cardiac oxidative stress biomarkers and histopathology.
Main Methods:
- Male Wistar albino rats were divided into Control, ISO, and CAR+ISO groups.
- Measurements included electrocardiography (ECG), serum troponin I, cardiac OS biomarkers (MDA, GSH, SOD, CAT), and histopathology.
- CAR was administered orally, while ISO was given subcutaneously.
Main Results:
- ISO significantly increased troponin I, QTc interval, and histopathological damage.
- ISO altered OS biomarkers, decreasing GSH and SOD while increasing MDA and CAT.
- CAR treatment significantly reduced troponin I levels, attenuated ECG abnormalities, restored OS biomarkers, and improved cardiac histopathology.
Conclusions:
- Carvacrol demonstrates significant cardioprotective effects against ISO-induced myocardial injury.
- CAR's protective mechanisms involve antioxidant, membrane-stabilizing, and anti-arrhythmic properties.
- CAR holds therapeutic potential for OS-mediated cardiac conditions, meriting further research.
