Related Experiment Video
Updated: Mar 31, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
From Design to Bioactivity: 2-Benzoylpyridine 4-(bicyclo[2.2.1]hept-2-yl)thiosemicarbazone and Its 3d Metal
Ianina Graur1, Vasilii Graur1, Elena Melnic2
1Laboratory of Advanced Materials in Biopharmaceutics and Technics, Institute of Chemistry, Moldova State University, Chisinau, Republic of Moldova.
Abstract:
The new 2-benzoylpyridine 4-(bicyclo[2.2.1]hept-2-yl)thiosemicarbazone (HL) and its copper(II), nickel(II), cobalt(III), and iron(III) coordination compounds [Cu(L)Cl] (1), [Cu(L)NO3] (2), {[Cu(L)(Cl2CHCOO)]}n (3), [Ni(HL)2](NO3)2 (4), [Fe(L)2]NO3 (5), [Co(L)2]NO3 (6) were obtained. The thiosemicarbazone HL was studied using 1H, 13C NMR, and FTIR spectroscopy. All the obtained 3d metal coordination compounds were characterized by elemental analysis and FTIR spectroscopy. The single-crystal X-ray diffraction analysis was used to determine the crystal structures of HL and complex 3. The study of antibacterial activity revealed that coordination of the thiosemicarbazone HL to the metal ions leads to an increase in activity. Whereas in the case of antifungal activity, the effect is the opposite-the activity either remains at the same level or decreases. Most of the complexes exhibited activity that surpassed the results obtained for the standard drugs Furacillinum, Nystatin, and Fluconazole.
More Related Videos
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
04:51Author Spotlight: Functionalizing Metal-Organic Frameworks: Advancements, Challenges, and the Power of Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Related Concept Videos
Valence Bond Theory
Coordination Number and Geometry
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Properties of Organometallic Compounds
Coordination Compounds and Nomenclature