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Updated: Mar 31, 2026

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis

Published on: January 16, 2013

Exploring the causal links among immune cell characteristics and prostatitis: a bidirectional two-sample Mendelian

Yi Wang^1,2, Cong Xue¹, Zhuxian Xu¹

¹Department of Urology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male

|March 30, 2026

Abstract

Purpose:

We aimed to conduct a bidirectional two-sample Mendelian randomization (MR) analysis to comprehensively explore the causal associations between prostatitis and 731 immune cell properties.

Methods:

A bidirectional two-sample MR analysis was conducted to reveal their causal correlations. Sensitivity analyses were performed to assess the robustness of the results.

Results:

A total of 12 immune cells were found to be significantly linked with prostatitis risks, including CD39+ secreting Treg AC, B cell AC, NK %CD3- lymphocyte, CD28+ CD45RA- CD8dim %T cell, CD3 on CM CD4+ , CD3 on CD45RA- CD4+ , CD3 on CD39+ secreting Treg, CD3 on CD28+ CD4+ , CD3 on CD28+ CD45RA- CD8br, CD3 on CD28+ CD45RA+ CD8br, PDL-1 on CD14- CD16-, and CD4 on CD39+ secreting Treg (all FDRs < 0.05). Prostatitis was also found to be significantly linked with 11 immunophenotypes, containing CD25 on IgD+ CD38- unsw mem, CD38 on CD3- CD19-, CD3 on naive CD8br, CD3 on Naive CD4+ , CD3 on CD39+ CD4+ , CD3 on CD4+ , CD14 on CD14+ CD16- monocyte, CD4 on CM CD4+ , CD4 on naive CD4+ , CD4 on CD45RA+ CD4+ , and CD4 on secreting Treg (all FDRs < 0.05).

Conclusions:

Our results suggest important associations between prostatitis and immune cell profiles, shedding light on the immune-related etiologies and phenotypes in prostatitis.

Keywords:

Mendelian randomization Prostatitis causal inference genetic variants immune cells

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