Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

665
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
665
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.6K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.6K
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

1.2K
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physical activity and social media addiction: a multi-mediation analysis.

Frontiers in psychologyĀ·2026
Same author

[Moxibustion promotes hematoma clearance in rats with intracerebral hemorrhage by up-regulating the expressions of PPARĪ³/CD36 and M2 phenotype polarization of microglia].

Zhen ci yan jiu = Acupuncture researchĀ·2026
Same author

Dynamic inflammatory biomarkers as prognostic indicators in advanced breast cancer patients receiving PD-1 inhibitors.

Therapeutic advances in medical oncologyĀ·2026
Same author

Camrelizumab Plus Nab-paclitaxel in Patients with Previously Treated Advanced Urothelial Carcinoma: A Multicenter Phase II Study.

Cancer communications (London, England)Ā·2026
Same author

Exploring the relationship between family support and eating behaviors among college students with subjective well-being as the central mediating variable.

Frontiers in psychologyĀ·2026
Same author

Cardioprotective effects of puerarin against myocardial ischemia-reperfusion injury: a preclinical systematic review and meta-analysis.

Frontiers in pharmacologyĀ·2026

Related Experiment Video

Updated: Mar 31, 2026

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
06:46

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis

Published on: January 16, 2013

16.7K

Exploring the causal links among immune cell characteristics and prostatitis: a bidirectional two-sample Mendelian

Yi Wang1,2, Cong Xue1, Zhuxian Xu1

  • 1Department of Urology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|March 30, 2026
PubMed
Summary

This study found significant causal links between prostatitis and 12 immune cell properties. Prostatitis also showed associations with 11 distinct immunophenotypes, highlighting the role of immune cells in the condition.

Keywords:
Mendelian randomizationProstatitiscausal inferencegenetic variantsimmune cells

More Related Videos

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
09:49

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Published on: August 13, 2015

9.9K
Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
08:30

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns

Published on: December 12, 2025

401

Related Experiment Videos

Last Updated: Mar 31, 2026

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
06:46

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis

Published on: January 16, 2013

16.7K
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
09:49

Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation

Published on: August 13, 2015

9.9K
Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
08:30

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns

Published on: December 12, 2025

401

Area of Science:

  • Immunology
  • Genetics
  • Urology

Background:

  • Prostatitis is a common urogenital condition with complex etiologies.
  • The role of immune system dysregulation in prostatitis pathogenesis is increasingly recognized.
  • Understanding the specific immune cell profiles associated with prostatitis is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the bidirectional causal relationships between prostatitis and a comprehensive set of immune cell properties.
  • To identify specific immune cell types and phenotypes causally linked to prostatitis risk.
  • To explore the immune-related etiologies and phenotypes underlying prostatitis.

Main Methods:

  • A bidirectional two-sample Mendelian randomization (MR) analysis was employed.
  • Utilized genetic variants associated with immune cell properties and prostatitis.
  • Performed sensitivity analyses to ensure the robustness and reliability of the findings.

Main Results:

  • Identified 12 immune cell properties significantly associated with prostatitis risk (FDR < 0.05).
  • Found significant associations between prostatitis and 11 distinct immunophenotypes (FDR < 0.05).
  • Specific immune cells like regulatory T cells (Tregs) and B cells showed notable links to prostatitis.

Conclusions:

  • The study establishes significant associations between prostatitis and various immune cell profiles.
  • Findings suggest a strong immune component in the development and manifestation of prostatitis.
  • Results provide insights into immune-related mechanisms contributing to prostatitis, potentially informing future therapeutic strategies.