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Related Experiment Video

Updated: Mar 31, 2026

Quantitative Assessment of Cortical Auditory-tactile Processing in Children with Disabilities
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Central auditory processing in children with sickle cell disease.

Heba G A Ali1, Mohamed A ElLaboudy1, Fatma Soliman Elsayed Ebeid1,2

  • 1Pediatric Hematology Oncology and BMT Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Pediatric Hematology and Oncology
|March 30, 2026
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Summary

Children with sickle cell disease (SCD) often experience auditory processing disorders (APD), particularly affecting auditory memory and patterning. Early screening for APD in SCD patients is crucial for timely intervention.

Keywords:
APDaudiologyauditory perceptionchildrensickle cell disease

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Area of Science:

  • Pediatric Hematology
  • Audiology
  • Neuroscience

Background:

  • Sickle cell disease (SCD) presents complex, multi-systemic challenges beyond hematological issues.
  • The auditory system is frequently affected in children with SCD, necessitating investigation into Central Auditory Processing (CAP).

Purpose of the Study:

  • To evaluate Central Auditory Processing (CAP) abilities in pediatric SCD patients.
  • To identify risk factors associated with Auditory Processing Disorders (APD) in children with SCD.

Main Methods:

  • A cross-sectional study involving 33 children (aged 6-16) diagnosed with SCD.
  • Comprehensive audiological assessments including pure tone audiometry, IQ testing, CAP abilities evaluation, and APD screening.
  • Analysis of demographic, clinical, and laboratory data.

Main Results:

  • All participants had normal pure tone audiometry; 2 had middle ear issues.
  • 84% of assessed children (n=21) exhibited Auditory Processing Disorders (APD).
  • Auditory memory (64%) and patterning (84%) were the most impacted CAP skills. A correlation was found between transfusion age and dichotic listening.

Conclusions:

  • Auditory Processing Disorders (APD) are prevalent in children with SCD.
  • Routine screening for APD is recommended for early detection and management in pediatric SCD patients.
  • Intervention strategies should address deficits in auditory memory and patterning.