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Cobalt-Catalyzed Carbonylative Conversion of Unactivated Alkyl Chlorides
Chao Xu1,2, Yuanrui Wang1, Guang Zeng3
1Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China.
None:
Unactivated alkyl chlorides are ideal but underutilized building blocks in carbonylation due to the high strength of C-Cl bonds and the limitations of existing transition-metal catalysis. Herein, we describe a Salen-cobalt-catalyzed carbonylative transformation of unactivated alkyl chlorides under mild conditions, enabled by the supernucleophilic Co(I) center that efficiently promotes SN2-type C-Cl activation. This system accommodates sterically hindered nucleophiles and proceeds through a well-supported radical-involved organocobalt catalytic cycle, providing a general platform for carbonylation of challenging alkyl chlorides.
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