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Goal Attainment Rate in Secondary Prevention in Taiwan - A Chang Gung Research Database Study

Tien-Yu Chen1,2, Chia-Chen Wu3, Yi-Ting Chen1

  • 1Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital.

Acta Cardiologica Sinica
|March 30, 2026
PubMed

Insights

Low-density lipoprotein cholesterol (LDL-C) goal attainment is poor in Taiwanese patients with atherosclerotic cardiovascular disease (ASCVD). Intensified lipid management and adherence to therapy are crucial for secondary prevention of cardiovascular events.

Area of Science:

  • Cardiology
  • Public Health
  • Pharmacology

Background:

  • Effective lipid control is vital for secondary prevention of cardiovascular disease (CVD).
  • Low-density lipoprotein cholesterol (LDL-C) goal attainment rates in high-risk Taiwanese patients are not well-established.

Purpose of the Study:

  • To evaluate LDL-C goal attainment and adherence to lipid-lowering therapy (LLT) in Taiwanese patients with atherosclerotic cardiovascular disease (ASCVD).

Main Methods:

  • Retrospective observational study of 116,228 ASCVD patients (2017-2021).
  • Analysis of LDL-C levels, LLT intensity, and goal attainment (< 70 mg/dL).
  • Multivariate logistic regression to identify factors associated with LDL-C goal attainment.

Main Results:

  • Only 12.2% achieved LDL-C < 70 mg/dL at baseline, improving to 25.1% at 12 months.
  • High-intensity LLT significantly increased the likelihood of goal attainment (RR 1.54, p < 0.001).
  • Male sex, diabetes, and prior PCI were positively correlated with goal attainment, but control remained suboptimal in cerebrovascular and peripheral artery disease subgroups.

Conclusions:

  • Real-world LDL-C goal attainment in Taiwanese ASCVD patients is low.
  • There is a need for intensified lipid management and improved adherence to guideline-based therapy.
  • Tailored interventions are necessary for non-CAD ASCVD patients to reduce cardiovascular risk.
Abstract

Keywords:
Cardiovascular diseaseLDL-C goal attainmentLipid-lowering therapySecondary prevention

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