Advancing biomedical technology through multifunctional porphyrin-based MOFs: design principles, applications, and...

Area of Science:

• Materials Science
• Nanomedicine
• Biomedical Engineering

Background:

• Porphyrin-based metal-organic frameworks (MOFs) possess advantageous properties for biomedical applications.
• These include excellent structural and functional characteristics, favorable biosafety, low toxicity, and biodegradability.

Purpose of the Study:

• To systematically review the design principles of porphyrin-based MOFs.
• To highlight their recent advancements and applications in various biomedical fields.
• To critically assess their biosafety and toxicity profiles.

Main Methods:

• Literature review focusing on porphyrin-based MOFs.
• Analysis of design strategies and synthesis methods.
• Evaluation of reported biomedical applications and safety data.

Main Results:

• Porphyrin-based MOFs are versatile materials with demonstrated potential in cancer therapy, antibacterial treatments, wound healing, and biosensing.
• Their intrinsic biodegradability and low toxicity contribute to their suitability for in vivo applications.
• Design principles allow for tailored functionalities for specific biomedical needs.

Conclusions:

• Porphyrin-based MOFs offer significant potential for clinical translation in biomedicine.
• Further research is needed to address current challenges and optimize their performance and safety.
• Multifunctional porphyrin-based MOFs are emerging as promising candidates for advanced therapeutic and diagnostic tools.