Advancing biomedical technology through multifunctional porphyrin-based MOFs: design principles, applications, and...

Porphyrin-based metal-organic frameworks (MOFs) have a great deal of promise for widespread use in biomedical and nanomedical fields because of their exceptional structural and functional properties, good biosafety and low toxicity, and intrinsic biodegradability. This review systematically outlines the design principles of porphyrin-based MOFs and highlights their latest developments in a variety of biomedical applications, including cancer therapy, antibacterial treatment, wound healing, and biosensors. Subsequently, we critically examine their biosafety and toxicity aspects. Finally, we detail the current state of the art, ongoing challenges, and future prospects for the emerging materials in biomedicine. With continued research efforts, multifunctional porphyrin-based MOFs have great potential for future clinical translation.