An implantable dual-chamber capsule with three release modes for site-specific delivery and enhanced therapeutic...

Precise and flexible drug delivery is increasingly required in clinical therapy, yet most implantable systems remain constrained by limited selectivity, low loading capacity, and bulky size. Here, we present an implantable capsule that employs magnetically actuated vibration of an internal metallic cantilever to achieve magnetically controlled release. The capsule integrates a dual-reservoir structure, enabling the device to load two drugs and support multimodal release through three independent modes. Experimental evaluation demonstrates a drug retention rate of 76% and a single release volume of 0.01 mL with fluctuations within ±0.0005 mL, while maintaining a miniature form factor (13 × 5 × 5 mm³) and stable performance under thermal (45 °C) and mechanical (50 g) stress. In vivo studies further confirm that insulin and lidocaine hydrochloride delivered by this capsule achieve therapeutic outcomes comparable to subcutaneous injection. Combining compactness, robustness, and multi-mode controllability, this system supports long-term implantable drug administration.