Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

842
Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
842
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

476
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
476
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.7K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.7K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

1.3K
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
1.3K
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

3.3K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
3.3K
Regulation of Metabolism01:19

Regulation of Metabolism

12.3K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
12.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural ventilation performance for airborne diseases management in a deployable treatment facility.

Infection control and hospital epidemiology·2026
Same author

New percentiles of gamma-glutamyl transferase serum levels in infants and the role of breastfeeding.

BMC pediatrics·2026
Same author

Advancing MSC-EV Therapies: Harnessing Preconditioning and Mito-EVs to Tackle Neuroinflammation and Neurodegeneration.

Pharmaceutics·2026
Same author

Occupational exposure to hexavalent chromium: a systematic review of environmental monitoring methods and analytical advances.

Annals of work exposures and health·2026
Same author

Welding Activities: Is EBC a Reliable Indicator for Assessing Metal Exposure or Early Biological Effects? A Systematic Review.

Journal of breath research·2026
Same author

A survey on occupational medicine residency programs across european countries.

BMC medical education·2026

Related Experiment Video

Updated: Mar 31, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

597

Association Between Shift Work and Metabolic Alterations: Possible Contributing Factors.

Veruscka Leso1, Pasquale Dolce2, Marco Greco1

  • 1Department of Public Health, Section of Occupational Medicine, University of Naples "Federico II", Naples, Italy.

Safety and Health at Work
|March 30, 2026
PubMed
Summary

Shift work (SW) increases the risk of metabolic syndrome (MetS) due to disrupted biological rhythms and poor sleep quality. Lifestyle, diet, and chronotype interact with SW to influence MetS development.

Keywords:
Health promotionHematological parametersNight workRisk assessment and managementWorker well-being

More Related Videos

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

13.0K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K

Related Experiment Videos

Last Updated: Mar 31, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

597
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

13.0K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K

Area of Science:

  • Occupational Health
  • Metabolic Health
  • Chronobiology

Background:

  • Shift work (SW) disrupts biological rhythms, sleep, metabolism, and eating behaviors, potentially leading to metabolic disorders.
  • Metabolic syndrome (MetS) is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.

Purpose of the Study:

  • To assess the relationship between shift work and physical/metabolic parameters, including MetS.
  • To investigate the roles of sleep quality, chronotype, chrononutrition, and Mediterranean diet in the development of MetS among shift workers.

Main Methods:

  • Cross-sectional study comparing shift workers (n=172) and non-shift workers (n=177).
  • Medical examinations, lab tests, and validated questionnaires (Pittsburgh Sleep Quality Index, Chrononutrition Profile, Morning-Eveningness, Mediterranean Diet).
  • MetS diagnosed using NCEP ATP III criteria.

Main Results:

  • Shift workers had significantly higher systolic blood pressure and a higher prevalence of MetS (25.6% vs. 13.7%).
  • Shift workers reported poorer sleep quality, a more frequent evening chronotype, and higher adherence to the Mediterranean diet.
  • No significant differences in chrononutrition profiles were observed between groups.

Conclusions:

  • Shift work is a significant risk factor for MetS.
  • The development of MetS in shift workers is multifactorial, influenced by lifestyle, diet, chronotype, sleep quality, and occupational factors.
  • An integrated approach addressing these interacting factors is crucial for workplace health and well-being.