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Updated: Mar 31, 2026
06:29
Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
Published on: July 30, 2020
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Aurora Kinase A: Integrating Insights into Cancer, Inflammation, and Infectious Diseases
Nidhi Varshney1, Rajan Kumar Pandey2, Amit Mishra3
1Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, India.
Gut Microbes Reports
|March 30, 2026
Summary
Aurora kinase A (AURKA) is vital for cell division and genomic stability, playing a key role in cancer. This review details AURKA
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Aurora kinase A (AURKA) is essential for cell division and genomic stability.
- AURKA's dysregulation is implicated in various cancers.
- Emerging evidence links AURKA to host-pathogen interactions and non-cancerous diseases.
Purpose of the Study:
- To comprehensively review the structural and functional roles of AURKA.
- To explore AURKA's involvement in cell cycle regulation, cancer, and infectious diseases.
- To highlight AURKA as a potential therapeutic target for diverse diseases.
Main Methods:
- Literature review of existing research on AURKA.
- Analysis of AURKA's structural and functional domains.
- Synthesis of data on AURKA's role in cell cycle, cancer, viral/bacterial infections, and autophagy.
Main Results:
- AURKA is a critical regulator of cell cycle progression and mitosis.
- AURKA contributes to oncogenesis through various mechanisms, including viral-mediated tumorigenesis and gut microbiome-linked cancers.
- AURKA influences inflammatory responses, cell death, autophagy, and DNA replication, independent of its kinase activity.
- AURKA's modulation in cytoplasmic and mitochondrial regions impacts its oncogenic effects.
Conclusions:
- AURKA possesses diverse biological functions extending beyond its canonical role in cell division.
- Understanding AURKA's multifaceted roles is crucial for developing novel therapeutic strategies.
- AURKA represents a promising drug target for cancer and potentially other diseases.
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