Related Experiment Video
Updated: Mar 31, 2026
10:18
Real-Time, Semi-Automated Fluorescent Measurement of the Airway Surface Liquid pH of Primary Human Airway Epithelial Cells
Published on: June 13, 2019
7.9K
Intracellular Chloride Channels: A Rising Target in Lung Disease Research.
Boina Baoyinna Borjigin1, Jing Zhao1,2, Harpreet Singh1
1Department of Physiology and Cell Biology, The Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Journal of Respiratory Biology and Translational Medicine
|March 30, 2026
Summary
Chloride intracellular ion channels (CLICs) are key to lung health, influencing conditions like cancer and inflammation. Understanding CLIC roles offers new therapeutic avenues for pulmonary disorders.
Area of Science:
- Molecular Biology
- Cell Biology
- Physiology
Background:
- Chloride intracellular ion channels (CLICs) are an understudied gene family with roles in cellular biology.
- CLICs exist in both membrane-bound and soluble forms, regulating chloride flux.
- Six mammalian CLIC isoforms have been identified and characterized.
Purpose of the Study:
- To review the expression and functional roles of CLICs in lung pathophysiology.
- To highlight the significance of CLIC1, CLIC3, and CLIC4 in pulmonary disorders.
- To explore the potential of CLICs as therapeutic targets for lung diseases.
Main Methods:
- Literature review of CLIC expression and function in the respiratory system.
- Analysis of CLIC involvement in lung carcinoma, inflammation, and endothelial dysfunction.
- Focus on specific CLIC isoforms (CLIC1, CLIC3, CLIC4) in pulmonary diseases.
Main Results:
- CLICs are expressed in the lung with distinct isoform patterns across cell types.
- CLIC1, CLIC3, and CLIC4 are implicated in lung cancer, inflammation, and pulmonary arterial hypertension.
- CLIC function is relevant to lung pathophysiology, including endothelial dysfunction.
Conclusions:
- CLICs play critical roles in regulating lung cellular function.
- Targeting CLICs may lead to novel therapeutic strategies for pulmonary disorders.
- Further research into CLIC mechanisms is warranted for effective treatment development.
Related Concept Videos
01:23Cystic Fibrosis: Pathogenesis
1.1K
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.1K
01:23Transcellular Transport of Solutes
5.3K
Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
5.3K
01:29Roles of Electrolytes: Chloride and Bicarbonate
1.3K
Chloride ions contribute to the osmotic pressure gradient distinguishing the intracellular fluid (ICF) from the extracellular fluid (ECF). They counterbalance positively charged ions in the ECF and ensure its electrochemical stability. The renal system's process of chloride absorption and release generally mirrors that of sodium ions.
Conditions such as hypochloremia can arise from insufficient chloride reabsorption by the kidneys, often compounded by extended bouts of diarrhea, vomiting,...
Conditions such as hypochloremia can arise from insufficient chloride reabsorption by the kidneys, often compounded by extended bouts of diarrhea, vomiting,...
1.3K
01:19Ligand-gated Ion Channels
15.5K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
15.5K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.1K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.1K
01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
4.8K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.8K