Immediate implant placement with and without platelet-rich fibrin and decalcified freeze-dried bone graft

There is a high risk of vertical and horizontal bone resorption in the peri-implant gap following immediate implant placement after non-molar tooth extraction, which compromises implant stability, hard/soft tissue preservation, and esthetic outcomes. The present study was a randomized controlled clinical trial included 40 patients requiring a single non-molar tooth extraction and immediate implant placement. Patients were randomly allocated into two equal groups (n=20). In the Test group, the peri-implant gap was filled with a composite of PRF and DFDBA. In the Control group, no grafting material was placed. The primary outcome was vertical bone level (VBL) change at 6 months, measured on standardized radiographs. Secondary outcomes included horizontal bone thickness changes measured on CBCT, implant stability quotient (ISQ) at baseline and 3 months and Pink Esthetic Score (PES) at 6 months. Independent t-tests were used for statistical analysis (α=0.05). The adjunctive use of a composite PRF and DFDBA graft in immediate implant placement sockets significantly improves the preservation of peri-implant hard and soft tissues, enhances secondary implant stability and leads to superior esthetic outcomes compared to no grafting.