Linking elastographic evaluation benign and malignant liver lesion with histopathological data

Differentiating benign from malignant focal liver lesions remains a significant diagnostic challenge with conventional imaging modalities. Acoustic Radiation Force Impulse (ARFI) elastography offers a non-invasive approach by quantitatively measuring tissue stiffness through shear wave velocity (SWV). ARFI elastography findings were compared with histopathology to assess diagnostic accuracy among 124 patients with focal liver lesions. Malignant lesions demonstrated significantly higher SWV values than benign lesions and a cutoff of 1.96 m/s achieved excellent sensitivity, specificity and overall accuracy. ARFI elastography is a highly reliable and superior adjunct to conventional ultrasound for non-invasive differentiation of benign and malignant liver lesions.