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Evaluation of orthognathic surgery planning with artificial intelligence: a prospective, comparative study
Enes Temizkan1, B Zeynep Yörük2, Banu Kılıç1
1Department of Orthodontics, Faculty of Dentistry, Bezmialem Vakıf University, Istanbul Türkiye.
European Oral Research
|March 30, 2026
Summary
Deep learning AI cephalometric analysis shows significant errors compared to 3D CT scans for orthognathic surgery planning. Further refinement of artificial intelligence algorithms is needed for reliable clinical application.
Area of Science:
- Dentistry
- Medical Imaging
- Artificial Intelligence
Background:
- Cephalometric analysis is crucial for orthognathic surgery planning.
- Traditional methods rely on manual measurements, which can be time-consuming and prone to error.
- Deep learning-based AI offers potential for automated cephalometric analysis.
Purpose of the Study:
- To evaluate the accuracy of AI-driven cephalometric analyses.
- To compare AI measurements against a 3D CT scan gold standard.
- To assess the reliability of AI tools (NemoCeph 2D, OrthoDx, AudaxCeph, WebCeph) in orthognathic surgery patients.
Main Methods:
- 3D CT scans were obtained from orthognathic surgery candidates.
- 3D cephalometric software established gold-standard landmark positions.
- AI programs automatically identified landmarks on 2D cephalometric images derived from 3D scans.
- Statistical analysis compared AI measurements with the 3D gold standard.
Main Results:
- The ANB angle showed no significant difference (p=0.061).
- Significant discrepancies (p<0.05) were found for SNA, SNB, Wits appraisal, Y Axis Angle, and facial height ratios.
- AI analyses demonstrated notable errors when compared to the 3D CT gold standard.
Conclusions:
- Current deep learning AI cephalometric analyses exhibit inaccuracies.
- These AI algorithms require further development for reliable use in orthognathic surgery planning.
- Clinical implementation of AI in this field necessitates algorithmic refinement.

