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Updated: Jul 19, 2026

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
Published on: September 18, 2015
Zn ion-implanted absorbable Fe for improved cytocompatibility and mitigated neointimal hyperplasia
Xueying Wang1, Hongyi Liu2,3, Mingjiang Sun2
1School of Materials Science and Engineering, Beihang University, Beijing 100191, China.
Abstract:
Ultrathin strut Fe-based scaffolds have made significant progress in the field of vascular interventional devices, but the issues of slow degradation and insufficient biocompatibility at the cell/material interface remain unresolved. This study prepared a functionalized surface on Fe by Zn ion implantation (Zn/Fe). Zn/Fe preferentially releases the antioxidant element Zn in the early degradation due to Zn-Fe galvanic coupling corrosion. It facilitates the adhesion and proliferation of endothelial cells and mitigates the risk of oxidative stress. The degradation rate of Zn/Fe was about 1.6 times that of Fe after 56 days of implantation in the common carotid artery of rats, with a 36.1% reduction in lumen loss rate, demonstrating favorable in vivo biocompatibility. These findings provide valuable insights for the development of novel functionalized Fe-based scaffold medical devices.
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