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Related Experiment Video

Updated: Jul 19, 2026

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

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Published on: September 18, 2015

Zn ion-implanted absorbable Fe for improved cytocompatibility and mitigated neointimal hyperplasia.

Xueying Wang¹, Hongyi Liu^2,3, Mingjiang Sun²

¹School of Materials Science and Engineering, Beihang University, Beijing 100191, China.

Regenerative Biomaterials

|March 30, 2026

Summary

Functionalized iron (Fe) scaffolds with zinc (Zn) ion implantation improve endothelial cell function and reduce blood vessel blockage. This novel Zn/Fe material shows enhanced biocompatibility for vascular interventional devices.

Keywords:

Fe-based alloy biodegradable ion implantation neointimal hyperplasia zinc

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Area of Science:

Biomaterials Engineering
Cardiovascular Devices
Surface Modification

Background:

Fe-based scaffolds are promising for vascular interventions but suffer from slow degradation and poor biocompatibility.
The cell/material interface is critical for scaffold performance and long-term success.

Purpose of the Study:

To develop a functionalized Fe-based scaffold with improved biocompatibility and degradation properties.
To investigate the effect of Zn ion implantation on Fe surface properties and in vivo performance.

Main Methods:

Prepared a functionalized Fe surface using Zn ion implantation (Zn/Fe).
Investigated Zn/Fe degradation and Zn ion release via Zn-Fe galvanic coupling corrosion.
Evaluated endothelial cell adhesion and proliferation on Zn/Fe.
Assessed in vivo biocompatibility and efficacy in a rat common carotid artery model.

Main Results:

Zn/Fe exhibited preferential Zn release, mitigating oxidative stress and promoting endothelial cell adhesion and proliferation.
The degradation rate of Zn/Fe was 1.6 times higher than Fe after 56 days.
Zn/Fe implantation resulted in a 36.1% reduction in lumen loss rate compared to Fe.

Conclusions:

Zn ion implantation is a viable strategy to enhance the biocompatibility and degradation profile of Fe-based vascular scaffolds.
Zn/Fe scaffolds demonstrate favorable in vivo performance, offering a promising alternative for vascular interventional devices.