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Updated: Mar 31, 2026
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
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Familial Risks in 317 000 Patients With Prostate Cancer in Relation to Metastases and Survival-Guiding Diagnostics.
Kari Hemminki1,2, Frantisek Zitricky1, Kristina Sundquist3,4,5
1Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czech Republic.
European Urology Open Science
|March 30, 2026
Summary
Prostate cancer (PC) risk significantly increases with multiple affected family members, with higher risks associated with more affected brothers. Familial PC cases show lower metastasis rates and better survival, highlighting the importance of family history in diagnosis and screening.
Area of Science:
- Oncology
- Genetics
- Epidemiology
Background:
- Swedish nationwide data provide a large resource for studying familial cancer.
- Focus on familial risks in prostate cancer (PC), including associations with metastatic disease and survival.
Purpose of the Study:
- To estimate familial relative risk of PC.
- To investigate the association between familial risk and metastatic disease and survival.
Main Methods:
- Standardized incidence ratios (SIRs) were used to estimate familial relative risk.
- Analysis considered men with affected fathers or brothers, categorized by number and type of affected relatives.
Main Results:
- Familial SIRs for PC ranged from 2.22 to 11.5, increasing with the number of affected brothers.
- Familial cases showed a lower proportion of metastases at diagnosis compared to non-familial cases.
- Survival in familial PC cases was better than in non-familial cases, particularly among patients without metastases.
Conclusions:
- Detailed family history is crucial for clinical decision-making and genetic counseling in prostate cancer.
- High familial risks suggest incorporating familial risk assessment into PC screening programs.
- Understanding familial risk can guide personalized management and treatment strategies for prostate cancer.
