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Updated: Mar 31, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Microwave-Assisted Deoxygenation of Substituted Aromatic Ketones over Commercial Pd/Al2O3 under Mild Conditions
Fabio Bucciol1, Ignacio C Vega1, Emanuela Calcio Gaudino1
1Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, Turin 10125, Italy.
Abstract:
Herein, a study on the deoxygenation of substituted aromatic ketones over commercial Pd/Al2O3 (5 wt %) is reported. The reaction occurs under very mild conditions (120 °C, 5 bar H2) in just 2 h using microwaves to enhance the kinetics. Ethanol was found to be the best solvent, while the effect of the substituents was studied over different substrates. On the basis of experimental evidence, a mechanism is proposed in which keto-enol tautomerization enables deoxygenation to the corresponding alcohol followed by direct hydrogenolysis to the alkyl chain.
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