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Nuclear Medicine in Depression: Insights into Brain Metabolism and Treatment Responses: a Literature Review
Raydel BrianKwee Amalo1, Hendra Budiawan1, Achmad Hussein Sundawa Kartamihardja1
1Department of Nuclear Medicine and Theranostic Molecular, School of Medicine, Hasan Sadikin General Hospital, Universitas Padjajaran, Bandung, Indonesia.
Abstract:
Depression is a prevalent mental health disorder with significant global impact, often accompanied by alterations in brain activity and neurotransmitter systems. Nuclear medicine, especially Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT), offers valuable insights into the neurobiological mechanisms underlying depression. These imaging modalities enable non-invasive assessment of cerebral glucose metabolism, neurotransmitter activity, and cerebral blood flow, which are often disrupted in individuals with depression. Advanced radiopharmaceuticals, including 18F-FDG PET, 123I-ADAM SPECT, and 11C-raclopride PET, have been utilized to explore the pathophysiology of depression and monitor responses to various treatment strategies. This review discusses how nuclear medicine enhances the diagnosis, understanding, and personalized management of depression, with potential for guiding therapeutic interventions based on brain activity patterns and treatment responses.
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