Current Prospects and Future Directions of Single Time Point Dosimetry in Radiopharmaceutical Therapy: A Systematic...

Area of Science:

• Medical Physics
• Nuclear Medicine
• Radiopharmaceutical Therapy

Background:

• Image-based dosimetry in radiopharmaceutical therapy offers personalized treatment but requires extensive scans and complex data processing.
• Clinical implementation faces hurdles due to the demanding nature of quantitative imaging and data analysis.
• Simplified methodologies are needed to improve the efficiency of personalized dosimetry.

Purpose of the Study:

• To systematically review the literature on single-time point (STP) dosimetry for organ dosimetry in patients undergoing radiopharmaceutical therapy.
• To evaluate the theoretical bases, practical applications, and clinical relevance of STP dosimetry.
• To assess the potential of STP dosimetry in balancing therapeutic efficacy and organ toxicity.

Main Methods:

• A systematic literature review was conducted following PRISMA guidelines.
• Databases searched included PubMed, ScienceDirect, Scopus, and Web of Science.
• Studies focused on organ dosimetry in patients using STP dosimetry from January 2012 to December 2023 were included.

Main Results:

• The review identified various applications of STP dosimetry in radiopharmaceutical therapy.
• Theoretical foundations and practical implementation strategies for STP dosimetry were outlined.
• The role of STP dosimetry in optimizing tumor control while minimizing healthy tissue exposure was discussed.

Conclusions:

• Single-time point (STP) dosimetry presents a promising simplification for personalized dosimetry in radiopharmaceutical therapy.
• It reduces the need for frequent imaging, enhancing clinical efficiency without compromising accuracy.
• STP dosimetry has the potential for routine clinical adoption, transforming radiopharmaceutical therapy practices.