Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

763
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
763
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

3.9K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.9K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

610
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
610
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

2.0K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.0K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

960
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
960

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative analysis of evoked haptic sensations by transcutaneous electrical nerve stimulation for electrode array size optimization.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same author

Calcium signaling pathway implicates a shared genetic basis between psychiatric and cardiovascular diseases.

Translational psychiatry·2026
Same author

Physics-informed graph inference and prediction for global state estimation in water distribution networks.

Water research·2026
Same author

Polymer-Zn(II) sunscreens for protection against harmful blue ray.

Bioactive materials·2026
Same author

Chemiluminescence functionalized magnetic nanoparticles-based biosensor for sensitive detection of glucose, uric acid, and cholesterol.

Analytical and bioanalytical chemistry·2026
Same author

Genome-wide pleiotropic analysis identifies shared genetic architecture within the cognition-immune nexus.

Translational psychiatry·2026

Related Experiment Video

Updated: Mar 31, 2026

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

3.3K

Obstructive Sleep Apnea Syndrome and Ischemic Stroke: Investigating Inflammatory Mechanisms.

Zihao Zhang1,2, Ziqing Zhu1,2, Zhiying Chen2,3

  • 1Department of Respiratory and Critical Care, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, 332000, People's Republic of China.

Nature and Science of Sleep
|March 30, 2026
PubMed
Summary

Obstructive Sleep Apnea Syndrome (OSAS) increases ischemic stroke risk by promoting inflammation via key signaling pathways. Early OSAS intervention may improve stroke outcomes and recovery.

Keywords:
inflammatory mechanismsischemic strokeobstructive sleep apnea syndromesignalling pathways

More Related Videos

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.7K
Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion
07:34

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion

Published on: March 1, 2019

12.5K

Related Experiment Videos

Last Updated: Mar 31, 2026

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

3.3K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.7K
Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion
07:34

Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion

Published on: March 1, 2019

12.5K

Area of Science:

  • Neurology
  • Sleep Medicine
  • Cardiovascular Research

Background:

  • Obstructive Sleep Apnea Syndrome (OSAS) involves airway collapse during sleep, causing intermittent hypoxia and sleep fragmentation.
  • OSAS is linked to increased risk and severity of ischemic stroke.
  • Inflammatory pathways are implicated in the OSAS-stroke connection.

Purpose of the Study:

  • To systematically review the mechanisms connecting OSAS and ischemic stroke.
  • To emphasize the roles of PI3K/Akt, Toll-like receptor signaling, and NLRP3 inflammasome in OSAS-related inflammation and stroke pathogenesis.
  • To explore OSAS impact on stroke recovery and discuss therapeutic strategies.

Main Methods:

  • Systematic literature review.
  • Analysis of signaling pathways (PI3K/Akt, Toll-like receptor, NLRP3 inflammasome).
  • Examination of OSAS effects on stroke recovery and prognosis.

Main Results:

  • OSAS triggers inflammatory responses through PI3K/Akt, Toll-like receptor, and NLRP3 inflammasome pathways.
  • These inflammatory mechanisms contribute to ischemic stroke development and progression.
  • Impaired sleep quality and cardiovascular stress from OSAS negatively affect stroke recovery.

Conclusions:

  • OSAS significantly contributes to ischemic stroke pathogenesis through specific inflammatory signaling pathways.
  • Early diagnosis and intervention for OSAS are crucial for reducing stroke recurrence and improving patient outcomes.
  • Targeting inflammation and managing OSAS are key strategies for better clinical management of ischemic stroke.