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Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
Obstructive Sleep Apnea Syndrome and Ischemic Stroke: Investigating Inflammatory Mechanisms
Zihao Zhang1,2, Ziqing Zhu1,2, Zhiying Chen2,3
1Department of Respiratory and Critical Care, School of Clinical Medicine, Jiujiang University, Jiujiang, Jiangxi, 332000, People's Republic of China.
Abstract:
Obstructive Sleep Apnea Syndrome (OSAS) is characterized by repeated episodes of complete (apnea) or partial (hypopnea) collapse of the upper airway during sleep, leading to chronic intermittent hypoxia and/or hypercapnia, and sleep fragmentation. This review systematically examines the mechanisms linking OSAS and ischemic stroke, with particular emphasis on the roles of the PI3K/Akt signaling pathway, Toll-like receptor signaling pathway, and NLRP3 inflammasome in OSAS-related inflammatory responses, and their contributions to the pathogenesis and progression of ischemic stroke. We also explore how OSAS affects stroke recovery through impaired sleep quality and increased cardiovascular stress, potentially worsening prognosis. This article discusses potential anti-inflammatory therapeutic strategies, underscores the importance of early OSAS intervention in reducing recurrence and improving outcomes, and offers new perspectives on OSAS-related ischemic stroke mechanisms and clinical management.
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