Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model01:15

One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model

713
The first-order absorption model for extravascular administration describes the rate at which a drug is absorbed and eliminated, following the principles of first-order kinetics. This model is vital as it provides a mathematical representation of drug behavior within the body. It also allows for the prediction and interpretation of drug absorption and elimination based on the rate of change in drug concentration over time. This model can be visualized as a plasma concentration-time profile...
713
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

392
Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
392
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

323
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
323
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

311
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
311
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

397
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
397
Noncompartmental Analysis: Mean Residence Time01:05

Noncompartmental Analysis: Mean Residence Time

709
According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
After the administration of a drug through intravenous bolus injection, the drug molecules are distributed throughout the body and remain there for varying periods. The MRT represents the average time these drug molecules stay in the...
709

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and validation of an interpretable machine learning model for predicting 5-year recurrence in breast cancer.

Frontiers in medicine·2026
Same author

HSSM: A Widely Applicable Toolbox for Hierarchical Bayesian Neurocognitive Modeling.

bioRxiv : the preprint server for biology·2026
Same author

Breaking the photosynthetic monopoly on carbohydrate production through artificial synthesis.

Biotechnology advances·2026
Same author

Lipid disturbance and neuroinflammation contribute to Aflatoxin B<sub>1</sub>-linked Parkinsonism: an in vitro, in vivo, and Parkinsonism patients' integrating evidence.

Environment international·2026
Same author

The Association Between "Weekend Warrior" Physical Activity Pattern and Neuropsychological Outcomes: A Systematic Review.

Behavioral sciences (Basel, Switzerland)·2026
Same author

Impacted and preserved sub-domains of cognitive control in schizophrenia.

Neuropsychologia·2026
Same journal

Neural posterior estimation on exponential random graph models: evaluating bias and implementation challenges.

Statistics and computing·2026
Same journal

Subgroup Analysis of Differential Networks with Latent Variables.

Statistics and computing·2026
Same journal

Non-negative matrix factorization algorithms generally improve topic model fits.

Statistics and computing·2026
Same journal

Approximating evidence via bounded harmonic means.

Statistics and computing·2026
Same journal

Optimal <i>F</i>-score Matching for Bipartite Record Linkage.

Statistics and computing·2026
Same journal

Accelerated inference for stochastic compartmental models with over-dispersed partial observations.

Statistics and computing·2026
See all related articles
  1. Home
  2. Efficient Inference In First Passage Time Models.
  1. Home
  2. Efficient Inference In First Passage Time Models.

Related Experiment Video

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
13:00

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments

Published on: January 23, 2017

10.4K

Efficient Inference in First Passage Time Models.

Sicheng Liu1, Alexander Fengler2, Michael J Frank2,3

  • 1Division of Applied Mathematics, Brown University, 182 George St, Providence, 02912, RI, USA.

Statistics and Computing
|March 30, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

We developed a faster algorithm for generalized drift diffusion models (GDDMs) used in cognitive neuroscience. This method accurately computes likelihood functions, improving statistical inference for decision-making models with dynamic parameters.

Keywords:
Cherkasov conditionattentiondrift diffusion modelfirst passage timelikelihood-based inferencenumerical methods

More Related Videos

Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language
09:27

Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language

Published on: October 13, 2018

10.9K
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
14:21

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

18.9K

Related Experiment Videos

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
13:00

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments

Published on: January 23, 2017

10.4K
Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language
09:27

Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language

Published on: October 13, 2018

10.9K
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
14:21

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

18.9K

Area of Science:

  • Computational cognitive neuroscience
  • Mathematical modeling
  • Statistical inference

Background:

  • First passage time models are crucial for analyzing random processes across scientific disciplines.
  • Generalized drift diffusion models (GDDMs) are vital in cognitive neuroscience for understanding decision-making by modeling latent psychological processes.
  • Current methods for computing GDDM likelihoods are inefficient when drift rates vary dynamically within trials.

Purpose of the Study:

  • To propose a novel, fast, and flexible algorithm for computing the likelihood function of GDDMs.
  • To address limitations of existing methods in scenarios with time-varying drift rates.
  • To enable more efficient statistical inference for complex GDDMs.

Main Methods:

  • Developed a new algorithm for GDDMs satisfying the Cherkasov condition.
  • The method segments trials into discrete stages.
  • Fast analytical results are used for stage-wise densities, which are then integrated for trial-wise likelihood computation.
  • Main Results:

    • The proposed algorithm provides accurate likelihood evaluations for statistical inference.
    • The method significantly outperforms existing approaches in terms of computational speed.
    • Demonstrated effectiveness through numerical examples for GDDMs with dynamic drift rates.

    Conclusions:

    • The new algorithm offers a substantial improvement for analyzing GDDMs, particularly in complex scenarios.
    • This advancement facilitates more efficient and accurate parameter estimation in computational cognitive neuroscience.
    • The method enhances the applicability of GDDMs to real-world data with dynamic covariates.